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Lancet. 1993 Feb 13;341(8842):407-8.

Pregnancy and fetal long-chain 3-hydroxyacyl coenzyme A dehydrogenase deficiency.

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1
Oliver Latham Laboratory, New South Wales Health Department, Sydney, Australia.

Abstract

We report on eleven pregnancies in 5 mothers. 6 of the babies had long-chain 3-hydroxyacyl coenzyme A dehydrogenase (LCHAD) deficiency, and each of the pregnancies was complicated by features such as fatty liver and HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome. By contrast, 3 of the mothers also gave birth to unaffected babies, and these pregnancies were largely uncomplicated. We conclude that there may be adverse effects on maternal liver function from a fetus with LCHAD deficiency. Heterozygosity in the mother cannot alone account for the adverse effects because of the segregation of these effects with fetal LCHAD status.

PMID:
8094173
DOI:
10.1016/0140-6736(93)92993-4
[Indexed for MEDLINE]

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