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Gynecol Invest. 1975;6(5):265-71.

Antibacterial activity of human cervical mucus.

Abstract

The antimicrobial property of human uterine cervical mucus was tested in three groups of women. Healthy women, using no contraception, women using an intrauterine device and women receiving hormonal treatment for contraception. Cervical mucus was taken on the 10th, 14th, 18th and 22nd day of the menstrual cycle. Cervical mucus had a strong inhibitory effect on the growth of Micrococcus lysodeicticus in all three groups. The strength of the inhibitory effect on the other microorganisms were in the following order: Staphylococcus albus, Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Candida albicans, Streptococcus haemolyticus, Streptococcus faecalis. Use of an intrauterine device did not affect the antimicrobial effect of cervical mucus. The use of hormonal contraceptive canceled the antimicrobial effect on the series of microorganisms, with the exception of M. lysodeicticus. The maximum inhibitory effect occurred on the 14th day and declined toward the end of the menstrual cycle.

PIP:

The antimicrobial character of uterine cervical mucus was studied in women using the Saf-T-Coil IUD, in women taking the oral contraceptive (OC) Metrulen-M, and healthy women using no contraception. Cervical mucus samples were obtained on Days 10, 14, 18, and 22 of the menstrual cycle. The growth of Micrococcus lysoducticus was strongly inhibited by cervical mucus in all groups. Other organisms whose growth was inhibited were, in order of strength, Staphylococcus albus, Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Candida albicans, Streptococcus haemolyticus, and Streptococcus faecalis. The presence of an IUD did not affect the antimicrobial potency of cervical mucus, but OC use abolished this effect on the microorganisms studied, w ith the exception of Micrococcus lysodiecticus. Maximum inhibition was apparent on Day 14 of the menstrual cycle, while minimal inhibition was observed toward the end of the cycle.

PMID:
809320
[Indexed for MEDLINE]

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