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Am J Obstet Gynecol. 1994 Sep;171(3):653-60.

Comparative placental transport of oral hypoglycemic agents in humans: a model of human placental drug transfer.

Author information

1
Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio 78284-7836.

Abstract

OBJECTIVE:

This study compares the human placental transport of glyburide, glipizide, chlorpropamide, and tolbutamide.

STUDY DESIGN:

The recirculating single cotyledon human placenta model tested maternal-to-fetal transport in term placentas perfused immediately after delivery. Drug levels were measured by high-performance liquid chromatography and liquid scintillation spectrometry, and transport rates were calculated by comparing maternal and fetal concentrations.

RESULTS:

The transport of these substances differed significantly over a tenfold range (analysis of variance, p < 0.0008). A significant association exists by multiple linear regression between drug transfer and molecular weight, dissociation constant, and the octanol-water partition coefficient (R2 = 0.91, p < 0.0001).

CONCLUSIONS:

There is significant variability in human placental transfer rates of the oral hypoglycemics, which strongly correlates with molecular properties. These data suggest that less fetal exposure may occur with second-generation sulfonylureas and anticipate that regression models may be useful in selecting agents that minimize placental transport to the fetus.

PMID:
8092211
DOI:
10.1016/0002-9378(94)90078-7
[Indexed for MEDLINE]

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