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Acta Haematol. 1994;91(3):115-8.

Influenza virus vaccine in B-cell chronic lymphocytic leukaemia patients.

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First Department of Medicine, National and Kapodistrian University, School of Medicine, Laikon General Hospital, Athens, Greece.


The clinical reaction and the immunological response to influenza virus vaccine were studied in 43 B-cell chronic lymphocytic leukaemia patients. The Vaxigrip vaccine was administered containing the antigens A/Ghizhou/54/89, A/Singapore/6/86, and B/Yamagata/16/88. The side-effects observed were minimal and well tolerated. Antibody production with titres > 1:20 on day 15 was observed at least for one antigen in 35 patients (81%). In 23 of them (63%) this response was retained on days 30 and 60. Patients with IgG levels (< 700 mg/dl) responded less well as compared to those having normal IgG levels (> 700 mg/dl).

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