Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 1994 Sep 30;265(5181):2091-3.

Mediation of c-Myc-induced apoptosis by p53.

Author information

1
Institut für Klinische Molekularbiologie und Tumorgenetik Forschungszentrum für Umwelt und Gesundheit, GSF, München, Germany.

Abstract

The cellular proto-oncogene c-myc is involved in cell proliferation and transformation but is also implicated in the induction of programmed cell death (apoptosis). The same characteristics have been described for the tumor suppressor gene p53, the most commonly mutated gene in human cancer. In quiescent mouse fibroblasts expressing wild-type p53 protein, activation of c-Myc was found to induce apoptosis and cell cycle reentry, preceded by stabilization of p53. In contrast, in quiescent p53-null fibroblasts, activation of c-Myc induced cell cycle reentry but not apoptosis. These results suggest that p53 mediates apoptosis as a safeguard mechanism to prevent cell proliferation induced by oncogene activation.

PMID:
8091232
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center