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Nature. 1994 Sep 22;371(6495):297-300.

The ancient regulatory-protein family of WD-repeat proteins.

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1
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Erratum in

  • Nature 1994 Oct 27;371(6500):812.

Abstract

WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.

PMID:
8090199
DOI:
10.1038/371297a0
[Indexed for MEDLINE]
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