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J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug;33(6):792-4.

Clonazepam as an augmenting agent in the treatment of childhood-onset obsessive-compulsive disorder.

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Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.


This case study is of a young man with childhood onset of severe obsessive-compulsive disorder (OCD). The patient had no clinical improvement during therapeutic trials of clomipramine, fluoxetine, and fluvoxamine, including buspirone augmentation. The patient consumed 50 tablets of fluoxetine in a suicide attempt and experienced a total remission of his OCD symptoms for the first time in his life. This remission lasted approximately 1 month and raises interesting questions about the mechanism of action of the serotonin reuptake inhibitors. Subsequently, the patient was able to achieve a 75% improvement in symptomatology when treated with a combination of fluoxetine and clonazepam. This open report suggests that clonazepam may be an effective augmentation agent to a serotonin reuptake inhibitor in the treatment of OCD.

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