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FEMS Microbiol Lett. 1994 Aug 1;121(1):71-6.

Variability of peptidoglycan surface density in Escherichia coli.

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1
Centro de Biología Molecular Severo Ochoa CSIC-UAM, Facultad de Ciencias (Biología), Madrid, Spain.

Abstract

Murein synthesis in Escherichia coli can be partially inhibited by D-methionine without concomitant alterations in growth and morphology. D-Methionine-treated cultures grow steadily for an indefinite time, therefore murein surface density should be reduced. Determination of this parameter in control and D-methionine-treated cells showed a severe reduction in the latter. Murein surface density increases drastically in resting cells, irrespective of the presence of D-methionine. Mutants in ponB are hypersensitive to D-methionine. Analysis of ponB strains revealed an important reduction in murein surface density. An approximately two-fold reduction in average surface density is apparently compatible with normal growth and division.

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