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J Clin Psychiatry. 1994 Feb;55(2):66-9.

Augmentation strategies with tricyclic or fluoxetine treatment in seven partially responsive panic disorder patients.

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1
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY.

Abstract

BACKGROUND:

Although panic disorder is generally responsive to single antidepressant pharmacotherapy, a substantial percentage of patients fail either to respond adequately or to maintain a therapeutic response.

METHOD:

The authors report on seven consecutive openly treated patients with panic disorder who showed inadequate antipanic responses to treatment regimens including either a tricyclic (TCA) or fluoxetine. Those patients taking a TCA had fluoxetine added and those patients taking fluoxetine had a TCA added.

RESULTS:

All seven patients showed an improvement in antipanic response to the combination treatment.

CONCLUSION:

The current case series is the first, to our knowledge, to suggest that the combination of a TCA and fluoxetine may provide a viable pharmacotherapeutic option for panic disorder patients who have failed to respond to an adequate trial of either a TCA or fluoxetine. Appropriate controlled studies are recommended.

PMID:
8077156
[Indexed for MEDLINE]
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