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J Hered. 1975 Mar-Apr;66(2):97-9.

Phenotypic-karyotypic localization of the human Rh-locus on chromosome 1.


Statistical evaluation of between homologue differences and cytogenetic banding techniques were utilized to identify a small but significant homologue difference in Alp. An inherited chromosome variant characterized by an apparent deletion of the region delimited by the band pia3 and the telomeric end (t1) of chromosome A1, with telomeric conservation, was found to be consistently present in 3 familial pedigree members who expressed the highly infrequent -D-blood group type (-D/-D-). The most likely interpretation is that both the difference in length and the difference in banding characteristics reflect a real difference in DNA content of these homologues.

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