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J Chromatogr A. 1994 Jul 15;674(1-2):73-86.

Confirmatory tests for drugs in the workplace by gas chromatography-mass spectrometry.

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Chemistry and Drug Metabolism Section, National Institute on Drug Abuse, Baltimore, MD 21224.


The Mandatory Guidelines for Federal Workplace Drug Testing Programs require the use of gas chromatography-mass spectrometry (GC-MS) for the confirmation of presumptive positive urine specimens. This review focuses upon GC-MS methods developed specifically for forensic confirmation of amphetamine, methamphetamine, 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (THC-acid), benzoylecgonine, morphine, codeine and phencyclidine in urine for purposes of workplace drug testing. In addition, current laboratory issues pertaining to each drug class are reviewed. Generally, drug assays utilized either liquid-liquid or solid-phase extraction methods, derivatization if necessary, and GC-MS detection operating in the selected ion monitoring mode or by full scan acquisition.

[Indexed for MEDLINE]

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