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Wei Sheng Wu Xue Bao. 1994 Apr;34(2):106-12.

[A plasmid-mediated SHV type extended-spectrum beta-lactamase in Beijing isolate of Enterobacter gergoviae].

[Article in Chinese]

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Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing.


By conjugation experiment, an extended-spectrum beta-lactamase (ESb1a) encoded on a transferable plasmid of approximately 60 Kilobases was found in a clinical strain of Enterobacter gergoviae isolated from Peking Union Medical College Hospital. Its E. coli transconjugant was resistant to all beta-lactams tested except cefoxitin and imipenem. Clavulanic acid, a classical beta-lactamase inhibitor, inhibited its activity. Hybridization with an intragenic probe for SHV-1 revealed that this ESb1a may be related to, or derived from SHV enzyme.

[Indexed for MEDLINE]

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