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Planta Med. 1994 Jun;60(3):214-7.

Pharmacokinetics of the garlic compound S-allylcysteine.

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1
Institute for OTC Research, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan.

Abstract

The pharmacokinetic behavior of S-allylcysteine (SAC), one of the biologically active transformation products from garlic, was investigated after oral administration to rats, mice, and dogs. SAC was rapidly and easily absorbed in the gastrointestinal tract and distributed mainly in plasma, liver, and kidney. The bioavailability was 98.2, 103.0, and 87.2% in rats, mice, and dogs, respectively. SAC was mainly excreted into urine in the N-acetyl form in rats; however, mice excreted both SAC and the N-acetyl form. The half-life of SAC was longer in dogs than in rats and mice.

PMID:
8073085
DOI:
10.1055/s-2006-959461
[Indexed for MEDLINE]
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