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Exp Neurol. 1994 Jul;128(1):27-33.

Expression of beta-amyloid precursor protein gene is developmentally regulated in human muscle fibers in vivo and in vitro.

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1
USC Neuromuscular Center, University of Southern California School of Medicine, Los Angeles 90017.

Abstract

Regenerating muscle fibers in 25 human muscle biopsies, obtained from patients with a variety of neuromuscular diseases, manifested increased mRNA for the beta-amyloid precursor protein (beta APP) that contains the Kunitz-type protease inhibitor (KPI) motif, whereas adult human muscle fibers were negative in their vast non-extrajunctional region. Aneurally cultured normal human muscle fibers also expressed strong KPI-beta APP mRNA signal, which became significantly down-regulated during muscle differentiation. Our study demonstrates that in human muscle KPI-beta APP mRNA is developmentally regulated, and it suggests that beta APP may play a role in human muscle development.

PMID:
8070521
DOI:
10.1006/exnr.1994.1109
[Indexed for MEDLINE]

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