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Mech Ageing Dev. 1975 Jan-Feb;4(1):41-57.

Effects of exygen-nitrogen (1:1) at 760 Torr on the life span and fine structure of Drosophila melanogaster.


Exposure of Drosophila melanogaster adult males to an atmosphere of O2-N2 (1:1) at 760 Torr resulted in a marked reduction of life span. Among the fine structural changes occurring in the oxygen-poisoned flies, the following were similar to age-related changes: ceroid-lipofuscin accumulation in the visceral organs, sponginess of the brain and accumulation of lamellated dense bodies in the nerve cells. Also, the oxygen-poisoned flies showed a loss of the cytoplasmic membranes of the sperm cells, an alteration which was previously found in y-irradiated, but not in normal senescent, flies. In our opinion, oxygen poisoning of Drosophila may provide a valid model of accelerated aging, at least in regard to peroxidation injury of cell organelles and ceroid-lipofuscin accumulation.

[Indexed for MEDLINE]

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