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J Am Geriatr Soc. 1994 Sep;42(9):933-6.

Serum vitamin B12 levels and incidence of dementia in a healthy elderly population: a report from the Bronx Longitudinal Aging Study.

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1
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461.

Abstract

OBJECTIVE:

To determine whether low serum B12 levels are associated with an increased incidence of dementing illness.

DESIGN:

Longitudinal cohort study, 5-year follow-up.

PARTICIPANTS:

Volunteer cohort of 410 nondemented ambulatory subjects aged 75 to 85 years.

MEASUREMENTS:

Annual serum B12 determinations and neuropsychological assessments including the Blessed Test of Information, Memory and Concentration (BIMC) and the Fuld Object Memory Evaluation (FOME). If subject met criteria for a major cognitive change (as defined by an increase of 4 or more points on the BIMC), a work-up that included CT, EEG, and neurologic assessment was performed. Clinical diagnoses were made according to established criteria.

RESULTS:

Mean serum B12 level of entire sample was 558 pg/mL. Twenty-two subjects had low B12 levels defined as values < 150 pg/mL. Three of these 22 subjects (13.6%) became demented, compared with 57 of 388 subjects (14.7%) with higher levels. The incidence of Alzheimer disease among the low B12 group was 4.5% compared with 7.5% in the higher B12 group. The mean B12 level at time of diagnosis in subjects who did develop Alzheimer disease was 551 pg/mL. There was no evidence of hematologic disorder among the 22 subjects with low B12. Of the 3 low B12 subjects who did become demented, none responded to monthly B12 injections.

CONCLUSION:

A low B12 level may not be a risk factor for dementia in general or Alzheimer disease in particular.

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