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Ann Neurol. 1994 Aug;36(2):237-9.

Decreased dopamine transporters with age in health human subjects.

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1
Medical Department, Brookhaven National Laboratory, Upton, NY 11973.

Abstract

The effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 21-63 years) using positron emission tomography and [11C]cocaine. The ratio of the distribution volume for [11C]cocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (r = 0.65, p < 0.0005). This results document an age-related decline in dopamine transporters in healthy individuals.

PMID:
8053661
DOI:
10.1002/ana.410360218
[Indexed for MEDLINE]
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