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Nature. 1994 Aug 18;370(6490):533-9.

Structure of ribonucleotide reductase protein R1.

Author information

1
Department of Molecular Biology, Swedish University of Agricultural Sciences, Uppsala.

Abstract

Ribonucleotide reductase is the only enzyme that catalyses de novo formation of deoxyribonucleotides and is thus a key enzyme in DNA synthesis. The radical-based reaction involves five cysteins. Two redox-active cysteines are located at adjacent antiparallel strands in a new type of ten-stranded alpha/beta-barrel, and two others at the carboxyl end in a flexible arm. The fifth cysteine, in a loop in the centre of the barrel, is positioned to initiate the radical reaction.

PMID:
8052308
DOI:
10.1038/370533a0
[Indexed for MEDLINE]

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