Format

Send to

Choose Destination
Nature. 1994 Aug 18;370(6490):527-32.

Phosphatidylinositol-3-OH kinase as a direct target of Ras.

Author information

1
Imperial Cancer Research Fund, London, UK.

Abstract

Ras (p21ras) interacts directly with the catalytic subunit of phosphatidylinositol-3-OH kinase in a GTP-dependent manner through the Ras effector site. In vivo, dominant negative Ras mutant N17 inhibits growth factor induced production of 3' phosphorylated phosphoinositides in PC12 cells, and transfection of Ras, but not Raf, into COS cells results in a large elevation in the level of these lipids. Therefore Ras can probably regulate phosphatidylinositol-3-OH kinase, providing a point of divergence in signalling pathways downstream of Ras.

PMID:
8052307
DOI:
10.1038/370527a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center