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FEBS Lett. 1994 Aug 1;349(2):205-9.

Existence of a molecular ruler in proteasomes suggested by analysis of degradation products.

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1
Max-Planck-Institut für Biochemie, Martinsried, Germany.

Abstract

Analysis of the degradation products from two proteins, the insulin B-chain and human hemoglobin, generated by archaebacterial Thermoplasma acidophilum 20 S proteasomes, revealed an unexpectedly broad specificity. In spite of the vast number of different peptides found, they fell into a rather narrow size range. This suggests that a molecular ruler exists which determines the length of the cleavage products.

PMID:
8050567
DOI:
10.1016/0014-5793(94)00665-2
[Indexed for MEDLINE]
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