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Biull Eksp Biol Med. 1993 Apr;115(4):371-2.

[Study of the antimutagenic properties of Angelica archangelica by the micronucleus test].

[Article in Russian]


The antimutagenic activity Angelica archangelica L. water and alcohol extracts thio-tepa against mutagenicity was investigated by the micronucleus test in mouse bone marrow and peripheral blood cells. The reduction of thio-tepa mutagenic activity was more prominent when the extracts were injected 2-hours before thio-tepa treatment as it could be seen at the simultaneous treatment. The observed reduction of micronucleus frequencies was up to 77%. No genotoxic effects of Angelica extracts had been seen at the concentrations 50-100 mg/kg.

[Indexed for MEDLINE]

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