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Trends Biochem Sci. 1994 Jul;19(7):289-93.

The IRS-1 signaling system.

Author information

1
Research Division, Joslin Diabetes Center, Boston, MA.

Abstract

Insulin-receptor substrate 1 (IRS-1) is a principal substrate of the receptor tyrosine kinase for insulin and insulin-like growth factor 1, and a substrate for a tyrosine kinase activated by interleukin 4. IRS-1 undergoes multisite tyrosine phosphorylation and mediates downstream signals by 'docking' various proteins that contain Src homology 2 domains. IRS-1 appears to be a unique molecule; however, 4PS, a protein found mainly in hemopoietic cells, may represent another member of this family.

PMID:
8048169
DOI:
10.1016/0968-0004(94)90007-8
[Indexed for MEDLINE]

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