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Trends Biochem Sci. 1994 May;19(5):201-5.

The glycine-rich sequence of protein kinases: a multifunctional element.

Author information

1
German Cancer Research Centre, Department of Pathochemistry and Molecular Biology of Mitosis, Heidelberg, Germany.

Abstract

Evolution favours the use of glycine-rich loops for nucleotide binding in proteins. In the large family of protein kinases, the catalytic domain of which has one of the highest degrees of conservation among all known proteins, the structure of the nucleotide-binding site differs from classical folds. We are now beginning to understand the multiple functional roles of the glycine-rich sequence in protein kinases and some of the structural constraints leading to its conservation.

PMID:
8048162
DOI:
10.1016/0968-0004(94)90022-1
[Indexed for MEDLINE]

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