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EMBO J. 1994 Jul 1;13(13):3211-7.

Telomerase activity in germline and embryonic cells of Xenopus.

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1
Cold Spring Harbor Laboratory, NY 11724.

Abstract

Telomerase is a ribonucleoprotein which synthesizes telomere repeats onto chromosome ends. Telomerase activity is involved in telomere length maintenance. We used Xenopus laevis as a model system to study the expression of telomerase activity in germline cells and during early development. We identified a non-processive telomerase activity in manually dissected nuclei of Xenopus stage VI oocytes. Telomerase activity was detected throughout oogenesis and embryogenesis. Telomerase was active in both S and M phase cell cycle extracts, suggesting that telomerase activity is not regulated with chromosomal DNA replication.

PMID:
8039513
PMCID:
PMC395213
[Indexed for MEDLINE]
Free PMC Article
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