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Curr Opin Neurobiol. 1994 Apr;4(2):245-51.

The mechanisms of schizophrenia.

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Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242-1057.


Current investigations of the mechanisms of schizophrenia usually employ one of three possible explanatory models: a single disease entity model, a multiple disease entity model, and a dimensions of psychopathology model. None of these is at present preeminent. These models are used to explore four different types of mechanisms that may produce the symptoms of schizophrenia: neurodevelopmental, neural circuitry, genetic/molecular mechanisms, and chemical anatomy.

[Indexed for MEDLINE]

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