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Biochem Biophys Res Commun. 1994 Jul 15;202(1):354-9.

Synergistic effect of choline and carnitine on acetylcholine synthesis in neuroblastoma NB-2a cells.

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Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa.


An influence of carnitine on acetylcholine synthesis from radiolabeled glucose was monitored in neuroblastoma NB-2a cells. Upon addition of carnitine the distribution of its derivatives was found significantly different than the values published for brain, the level of long-chain acyl derivatives being much higher and reaching 60%. Carnitine itself did not change acetylcholine level. Together with choline (20 microM), carnitine was observed to stimulate (by 36%) acetylcholine synthesis in a synergistic way, which indicated that both substrates could be limiting factors of this process in NB-2a cell line of neuroblastoma.

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