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Biochem J. 1994 Jul 1;301 ( Pt 1):9-12.

Highly sensitive control of transcriptional activity by factor heterodimerization.

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1
Institut de Recherche Interdisciplinaire, Faculté de Médecine, Université Libre de Bruxelles, Belgium.

Abstract

Several molecular mechanisms have been proposed to explain highly sensitive controls of cellular functions by effector molecules. Here we study an equilibrium model describing the regulation of transcriptional activity through the heterodimerization of transcription factors. We demonstrate that this model involves a new type of biochemical control which accounts for a very high sensitivity.

PMID:
8037697
PMCID:
PMC1137134
[Indexed for MEDLINE]
Free PMC Article
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