A new UV-filter compound in human lenses

R J Truscott; A M Wood; J A Carver; M M Sheil; G M Stutchbury; J Zhu; G W Kilby

doi:10.1016/0014-5793(94)00601-6

A new UV-filter compound in human lenses

FEBS Lett. 1994 Jul 11;348(2):173-6. doi: 10.1016/0014-5793(94)00601-6.

Authors

R J Truscott¹, A M Wood, J A Carver, M M Sheil, G M Stutchbury, J Zhu, G W Kilby

Affiliation

¹ Australian Cataract Research Foundation, University of Wollongong, N.S.W.

PMID: 8034036
DOI: 10.1016/0014-5793(94)00601-6

Abstract

A new UV-filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside, has been identified in human lenses. The structure suggests that it is derived biosynthetically from tryptophan. Quantification studies on the new compound show that it is the second-most abundant UV-filter compound in the lens with an absorption and fluorescence spectrum similar to that of 3-hydroxykynurenine glucoside.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Crystallins / chemistry
Crystallins / isolation & purification*
Filtration
Glucosides / chemistry
Glucosides / isolation & purification*
Humans
Lens, Crystalline / chemistry*
Molecular Structure
Phenylbutyrates / chemistry
Phenylbutyrates / isolation & purification*
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Ultraviolet Rays*

Substances

Crystallins
Glucosides
Phenylbutyrates
4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside