Send to

Choose Destination
Cell Struct Funct. 1993 Dec;18(6):427-36.

Microsomal aldehyde dehydrogenase or its cross-reacting protein exists in outer mitochondrial membranes and peroxisomal membranes in rat liver.

Author information

Department of Physiology, Kansai Medical University, Osaka, Japan.


We investigated the subcellular distribution of microsomal aldehyde dehydrogenase (msALDH) in rat liver and revealed by the immunoblotting method that msALDH or a cross-reacting 54-kDa protein(s) exists in the outer mitochondrial membranes and peroxisomes. Anti-msALDH antibody markedly inhibited the decanal aldehyde dehydrogenase activity of the outer mitochondrial membranes as well as that of the microsomes. Immunogold electron microscopic observations showed that gold particles are localized over the ER, outer mitochondrial membranes and peroxisomal membranes. These results suggest that msALDH or its cross-reacting related protein is distributed not only in the ER membranes but also in the mitochondrial outer membranes and peroxisomal membranes.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center