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Arch Virol Suppl. 1994;9:485-94.

Cell surface receptor for ecotropic host-range mouse retroviruses: a cationic amino acid transporter.

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1
Department of Biochemistry, Oregon Health Sciences, University Portland.

Abstract

The cell surface receptor for ecotropic host-range murine leukemia viruses is a sodium-independent transporter for essential cationic acids. Our evidence strongly identifies this receptor as the transporter system y+, which was previously characterized by transport assays. Mutational analysis indicates that transporter activity is not necessary for viral reception. Infection of cells with ecotropic retroviruses causes only a partial down-modulation of receptor expression on cell surfaces.

PMID:
8032277
[Indexed for MEDLINE]
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