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Curr Opin Genet Dev. 1994 Apr;4(2):281-91.

Position-effect variegation and the new biology of heterochromatin.

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Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037-1099.


The phenomenon of position-effect variegation has long been used as evidence for the importance of chromosome position to gene expression in eukaryotes. Investigations published within the past few years demonstrate that position-effect variegation is caused by multiple mechanisms, and that direct tests of hypotheses are possible with numerous model systems.

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