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Curr Opin Genet Dev. 1994 Apr;4(2):255-9.

Role of DNA methylation in the regulation of transcription.

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Department of Cellular Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel.


DNA methylation plays an important role in the regulation of gene expression during development. Methyl moieties at CpG residues suppress transcription by affecting DNA-protein interactions, thus altering the accessibility of genes to trans-acting factors in the cell. Because it works in cis, this mechanism is important in the control of X inactivation and genomic imprinting.

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