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Neurosci Lett. 1994 Feb 28;168(1-2):243-6.

Identification of GABAA receptor subunits expressed in bovine adrenal medulla.

Author information

1
Instituto de Bioquímica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.

Abstract

The GABAA receptor subunits expressed in adrenal medulla have been characterized by radioligand binding and by immunological methods. The receptors were purified by both benzodiazepine affinity chromatography and anti-alpha 1 413-429 GABAA receptor antibody immunoaffinity chromatography. These preparations were screened by immunoblotting using GABA receptor alpha subunit sequence-specific antibodies. Results showed the existence of the alpha 1 subunit. Thus, the GABAA receptors expressed in adrenal medulla are homogeneous with respect to their alpha subunit complement and consistent with type BZ1 benzodiazepine receptor pharmacology.

PMID:
8028785
DOI:
10.1016/0304-3940(94)90460-x
[Indexed for MEDLINE]

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