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J Appl Toxicol. 1994 Mar-Apr;14(2):111-3.

Clinical effects of organophosphorus cholinesterase inhibitors.

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  • 1Chemical Casualty Care Office, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21014.


Nerve agents, highly toxic organophosphorus cholinesterase inhibitors, inhibit acetylcholinesterase and cause an accumulation of acetylcholine. Clinical effects depend on the route and amount of exposure and include miosis, bronchoconstriction, excessive secretions, vomiting, seizures, and cessation of respiratory and cardiac activity. Eye effects include miosis, engorgement of ocular vessels, pain, and decrease in light sensitivity. Therapy consists of atropine, a cholinesterase reactivator (pralidoxime), and ventilation as needed.

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