Format

Send to

Choose Destination
FEBS Lett. 1994 Jul 4;348(1):89-92.

Neuromedin B receptor, expressed in Xenopus laevis oocytes, selectively couples to G alpha q and not G alpha 11.

Author information

1
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.

Erratum in

  • FEBS Lett 1994 Aug 1;349(2):318.

Abstract

G-proteins of the q family have been implicated as mediators of bombesin receptors action. We cloned Xenopus G alpha q and G alpha 11 and specifically disrupted the synthesis of either protein with selective antisense oligonucleotides. G alpha q antisense inhibited responses mediated by neuromedin B receptor (NMB-R) by 74%, though not by gastrin-releasing peptide receptor (GRP-R). G alpha 11 antisense had little effect on either GRP-R- or NMB-R-mediated responses. This suggests that NMB-R couples to G alpha q, and that GRP-R and NMB-R show distinct G-protein coupling preferences in the Xenopus oocyte.

PMID:
8026589
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center