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Curr Opin Cell Biol. 1994 Apr;6(2):247-52.

The regulation of B- and T-lymphocyte activation by the transmembrane protein tyrosine phosphatase CD45.

Author information

1
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110.

Abstract

The expression of transmembrane protein tyrosine phosphatase CD45 is required for antigen-induced activation of T and B lymphocytes. During the past year, advances have been made in our understanding of CD45 regulation and its role in regulating Src-family members. The importance of CD45 in thymocyte maturation has been demonstrated through the generation of CD45-knockout mice.

PMID:
8024816
DOI:
10.1016/0955-0674(94)90143-0
[Indexed for MEDLINE]

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