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Curr Opin Cell Biol. 1994 Apr;6(2):198-203.

The active role of beta gamma in signal transduction.

Author information

1
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235-9041.

Abstract

Many receptors that sense the environment effect intracellular regulation through stimulation of heterotrimeric G proteins and the consequences thereof. While prominence was originally given to the alpha-subunits of G proteins as the pathway for downstream regulation, very active roles for the beta gamma-subunits have emerged in the past year. Recent experiments highlight the versatility of beta gamma-subunits in these regulatory pathways, but also emphasize some fundamental questions that remain.

PMID:
8024810
DOI:
10.1016/0955-0674(94)90136-8
[Indexed for MEDLINE]

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