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JAMA. 1994 Jul 20;272(3):231-3.

Hemochromatosis, multiorgan hemosiderosis, and coronary artery disease.

Author information

1
Division of Cardiology, University of Maryland Medical System, Baltimore.

Abstract

OBJECTIVE:

To examine the prevalence of coronary artery disease (CAD) in autopsies of patients with iron-overload syndromes.

DESIGN:

Retrospective autopsy study of CAD in cases of hemochromatosis and multiorgan hemosiderosis.

SETTING:

Registry of nearly 48,000 autopsies performed at The Johns Hopkins Hospital between 1889 and 1992.

SUBJECTS:

One hundred twenty-three subjects were studied. In a 2:1 control-case ratio, 82 controls matched by age, race, and sex were compared with 41 cases with iron overload.

MAIN OUTCOME MEASURE:

Severity of CAD.

RESULTS:

Pathological description of the coronary arteries were recorded as advanced or severe in 12% of iron-overload cases (n = 41) (mean age, 57.6 +/- 13.2 years) compared with 38% of controls (n = 82) (mean age, 57.0 +/- 13.8 years) (P = .01). The prevalence of three-vessel disease assessed by postmortem coronary arteriography was 11.1% in iron-overload cases (n = 18) (mean age, 61.7 +/- 12.2 years) compared with 33.3% in controls (n = 36) (mean age, 61.1 +/- 12.5 years) (P = .04). The odds ratio of CAD with iron overload was 0.18 (95% confidence interval, 0.04 to 0.73).

CONCLUSIONS:

Iron overload resulting from hemochromatosis or multiorgan hemosiderosis is not associated with an increased prevalence of CAD.

PMID:
8022042
[Indexed for MEDLINE]

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