Abstract
Karounidiol [D:C-Friedo-oleana-7,9(11)-diene-3 alpha,29-diol] and 7-oxodihydrokarounidiol [7-oxo-D:C-friedo-olean-8-ene-3 alpha,29-diol], isolated from the seeds of Trichosanthes kirilowii, were examined for the effect on 12-O-tetradecanoylphorbol-13-acetate (TPA, 1 microgram/ear)-induced inflammation, following application of this tumor-promoting agent, to the ears of mice. Both compounds inhibited the inflammatory activity induced by TPA and the 50% inhibitory dose for TPA-induced inflammation was 0.3 and 0.4 mg/ear, respectively. Furthermore, at 2 mumol/mouse, karounidiol markedly suppressed the promoting effect of TPA (1 microgram/mouse) on skin tumor formation in mice following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene / toxicity
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Animals
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Anticarcinogenic Agents / pharmacology*
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Cocarcinogenesis
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Female
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Inflammation / chemically induced
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Inflammation / prevention & control
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Mice
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Mice, Inbred ICR
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Oleanolic Acid / analogs & derivatives
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Oleanolic Acid / pharmacology
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Papilloma / chemically induced
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Papilloma / pathology
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Papilloma / prevention & control
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Skin Neoplasms / chemically induced
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Skin Neoplasms / pathology
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Skin Neoplasms / prevention & control
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Tetradecanoylphorbol Acetate / toxicity*
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Triterpenes / pharmacology*
Substances
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Anticarcinogenic Agents
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Triterpenes
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karounidiol
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7-oxodihydrokarounidiol
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9,10-Dimethyl-1,2-benzanthracene
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Oleanolic Acid
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Tetradecanoylphorbol Acetate