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Trends Biochem Sci. 1994 Apr;19(4):172-6.

Poly(ADP-ribose) polymerase: a molecular nick-sensor.

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Institut de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique, Unité de Cancérogénèse et Mutagénèse Moléculaire et Structurale, Strasbourg, France.

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  • Trends Biochem Sci 1994 Jun;19(6):250.


Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genotoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and function of this abundant and highly conserved enzyme.

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