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Science. 1994 Jul 1;265(5168):103-6.

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

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1
Institute for Genetics, University of Cologne, Germany.

Abstract

Deletion of the promoter and the first exon of the DNA polymerase beta gene (pol beta) in the mouse germ line results in a lethal phenotype. With the use of the bacteriophage-derived, site-specific recombinase Cre in a transgenic approach, the same mutation can be selectively introduced into a particular cellular compartment-in this case, T cells. The impact of the mutation on those cells can then be analyzed because the mutant animals are viable.

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PMID:
8016642
[Indexed for MEDLINE]

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