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Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6040-4.

Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily.

Author information

1
Department of Human Oncology, University of Wisconsin, Madison 53792.

Abstract

We have identified a member of the steroid receptor superfamily and cloned it from human and rat hypothalamus, prostate, and testis cDNA libraries. The open reading frame between first ATG and terminator TGA can encode 615 (human) and 596 (rat) amino acids with calculated molecular mass of 67.3 (human) and 65.4 (rat) kDa. The amino acid sequence of this protein, called TR4 orphan receptor, is closely related to the previously identified TR2 orphan receptor. The high homology between TR2 and TR4 orphan receptor suggests that these two orphan receptors constitute a unique subfamily within the steroid receptor superfamily. These two orphan receptors are differentially expressed in rat tissues. Unlike TR2 orphan receptors, the TR4 orphan receptor appears to be predominantly located in granule cells of the hippocampus and the cerebellum, suggesting that it may play some role(s) in transcriptional regulation in these neurons.

PMID:
8016112
PMCID:
PMC44133
DOI:
10.1073/pnas.91.13.6040
[Indexed for MEDLINE]
Free PMC Article

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