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Br J Urol. 1994 May;73(5):504-7.

Treatment of interstitial cystitis with intravesical heparin.

Author information

1
Division of Urology, University of California, San Diego Medical Center.

Abstract

OBJECTIVE:

To control the symptoms of interstitial cystitis with chronic self-administered intravesical heparin and determine whether the drug's continued use can sustain remission.

PATIENTS AND METHODS:

A total of 48 patients were selected to undergo intravesical heparin therapy, 10,000 units in 10 ml sterile water, three times per week for 3 months. For patients who attained a good clinical remission, therapy was available for up to a further 9 months.

RESULTS:

At 3 months 27 of 48 patients (56%) attained good clinical remissions. All were offered continuous therapy and 23 elected for an additional 3 months. Twenty of the 23 continued in remission. Sixteen of these patients elected to have a further 6 months of therapy (12 months total) and 15 of 16 remained in remission.

CONCLUSION:

In over half of the patients studied, intravesical heparin controls the symptoms of interstitial cystitis with continued improvement even after one year of therapy.

PMID:
8012771
[Indexed for MEDLINE]

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