Format

Send to

Choose Destination
Nat Genet. 1994 Mar;6(3):305-9.

Mosaic and polymorphic imprinting of the WT1 gene in humans.

Author information

1
Department of Human Genetics, Nagasaki University School of Medicine, Japan.

Abstract

We have examined the imprinting of the Wilms' tumour suppressor gene (WT1) in human tissues. We confirm that WT1 is biallelically expressed in the kidney, however, in five of nine preterm placentae WT1 was expressed largely or exclusively from the maternal allele. Monoallelic expression of WT1 was also found in two fetal brains. These data demonstrate that WT1 can undergo tissue specific imprinting. Furthermore, because monoallelic expression of WT1 was not found in all placentae examined, WT1 imprinting may be genetically polymorphic within the human population.

PMID:
8012395
DOI:
10.1038/ng0394-305
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center