Send to

Choose Destination
Annu Rev Physiol. 1994;56:711-39.

Hormonal signaling and regulation of salt and water transport in the collecting duct.

Author information

Department of Medicine, Veterans Administration Medical Center, Nashville, Tennessee.


The regulation of transport in the collecting duct is under multi-hormonal control. Vasopressin stimulates water and cation transport, primarily through a V2/Gs-coupled receptor that activates adenylyl cyclase, which raises cAMP. These stimulatory effects are damped by the action of several hormones, including vasopressin itself, which activate inhibitory G proteins, stimulate phospholipid breakdown, increase prostaglandin production, raise intracellular Ca2+, activate protein kinase C, stimulate tyrosine kinases, and raise cGMP. These inhibitory signals interact with the stimulatory, cAMP-coupled signaling pathway at multiple levels. The balance between these pathways controls net salt and water transport in the collecting duct.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center