Send to

Choose Destination
See comment in PubMed Commons below
Neurosurgery. 1994 Apr;34(4):740-3; discussion 743-4.

Creutzfeldt-Jakob disease transmitted by a cadaveric dura mater graft.

Author information

Department of Neurosurgery, Toranomon Hospital, Tokyo, Japan.


We report a case of Creutzfeldt-Jakob disease developing in a 31-year-old woman 56 months after she received a cadaveric dura mater graft after the removal of a giant pituitary adenoma. Creutzfeldt-Jakob disease was confirmed by a brain autopsy and the existence of an abnormal isoform of prion protein, verified by both immunohistochemical and Western blot analysis. Moreover, prion protein gene analysis was shown in this case to possess a wild-type genotype. The characteristics of Creutzfeldt-Jakob disease after a cadaveric dura mater graft are reviewed and discussed.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center