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Neurosurgery. 1994 Apr;34(4):737-9; discussion 739-40.

Creutzfeldt-Jakob disease in a pregnant woman with an implanted dura mater graft.

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Department of Pathology, Duke University Medical Center, Durham, North Carolina.


A 28-year-old woman with prior neurosurgery involving the placement of a cadaveric dural graft developed a rapidly progressive neurodegenerative disorder with prominent cerebellar dysfunction that was proven at autopsy to be Creutzfeldt-Jakob disease. She represents the second American to develop Creutzfeldt-Jakob disease in association with a dural graft. The unusual features of the case include the patient's initial clinical presentation with cerebellar ataxia in the absence of dementia, the widespread presence of kuru-type amyloid plaques on a histological examination of the brain, the development of clinical symptoms during pregnancy, and the subsequent delivery of a child who remains healthy at the age of 3 years.

[Indexed for MEDLINE]

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