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Life Sci. 1994;55(3):PL61-5.

CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil.

Author information

1
Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201.

Abstract

The adenosine A2 receptor antagonist CGS 15943 (0.1 mg/kg, i.p.) was tested for cerebroprotective activity in a gerbil stroke model. CGS 15943 markedly reduced stroke injury assessed by locomotor activity monitoring and by histopathological measurement of hippocampal CA1 pyramidal cell injury. It is proposed that a previously demonstrated reduction in the ischemia/reperfusion-evoked release of excitotoxic amino acids following CGS 15943 administration could account for its cerebroprotective actions.

PMID:
8007757
DOI:
10.1016/0024-3205(94)00889-2
[Indexed for MEDLINE]

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