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Int J Radiat Oncol Biol Phys. 1994 Jun 15;29(3):473-9.

Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI.

Author information

1
Dept. Radiology, School of Medicine (BRB-3), Case Western Reserve University, Cleveland, OH 44106.

Abstract

PURPOSE:

The differential effects on blood perfusion of the vasodilator hydralazine (HYD) between tumor and normal muscle have been measured using the dynamic enhanced-magnetic resonance imaging (DE-MRI) technique.

METHODS AND MATERIALS:

DE-MRI is a noninvasive method of determining blood perfusion in tumors and normal tissues using the MR contrast agent Gd-DTPA. Hydralazine is currently being used in an attempt to increase tumor response to bioreductive agents and to hyperthermia.

RESULTS:

We show that a dose of 1.2 mg/kg HYD causes an increase in tumor perfusion while doses > or = 2.5 mg/kg cause a decrease in tumor perfusion. The latter was accompanied by a dose-dependent increase in normal muscle perfusion consistent with the "steal effect."

CONCLUSION:

This study demonstrates the sensitivity of the DE-MRI technique and its capability of providing estimates of blood perfusion in normal and tumor tissue as well as in smaller regions of a solid tumor. Such features would make it clinically useful in the study of tumor response to radiation therapy and chemotherapy in patients.

PMID:
8005802
DOI:
10.1016/0360-3016(94)90441-3
[Indexed for MEDLINE]

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