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Cancer. 1994 Jul 1;74(1):100-3.

Oral etoposide in the treatment of hormone-refractory prostate cancer.

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Section of Hematology/Oncology, VA Medical Center, Allen Park, Michigan 48101.



Hormone-refractory prostate cancer generally remains a chemotherapy-resistant tumor and therefore warrants the continued evaluation of promising agents.


Twenty-two eligible patients with hormone-refractory prostate cancer were treated with oral etoposide at a dosage of 50 mg/m2/day for 21 days in a 28-day cycle. Response was evaluated using standard solid tumor response criteria.


There were two partial responses of 6 and 14 months' duration, respectively. Two patients had disease stabilization, one for 6 months and one for 12 months. Median survival was 31 weeks, with an overall 1-year survival of 30%. Reversible alopecia and myelosuppression were the primary toxicities noted.


Single-agent oral etoposide has minimal activity in patients with hormone-refractory prostate cancer.

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